Fairbanks is a home rule city and the borough seat of the Fairbanks North Star Borough in the U.S. state of Alaska.Fairbanks is the largest city in the Interior region of Alaska. 2016 estimates put the population of the city proper at 32,751, and the population of the Fairbanks North Star Borough at 100,605, making it the second most populous metropolitan area in Alaska (after Anchorage). The Metropolitan Statistical Area encompasses all of the Fairbanks North Star Borough and is the northernmost Metropolitan Statistical Area in the United States, located 196 driving miles (or 140 air miles) south of the Arctic Circle. Fairbanks is home to the University of Alaska Fairbanks, the founding campus of the University of Alaska system.