Eastmain (Cree: ᐄᔅᒣᐃᓐ/Îsmein) is a Cree community located on east coast of James Bay at the mouth of the Eastmain River, Quebec, Canada. It is a small coastal Cree village with a population of 767 people at the 2011 census. Its alternate Cree name is ᐙᐸᓅᑖᐤ/Wâpanûtâw, meaning Lands east of James Bay.
Like the other coastal villages on Hudson and James Bay, Eastmain was settled around a Hudson's Bay Company trading post, which was originally called East Main House. Some Cree settled there for ease in trading.
Eastmain is accessible by air (Eastmain River Airport) and by car over a gravel road linking it to the James Bay Road.
The Eastmain community was greatly affected by the James Bay Project, which in 1980 diverted 90% of the Eastmain River to the La Grande River.