The Stikine River (Tlingit: Shtax'héen) is a river, historically also the Stickeen River, approximately 610 km (379 mi) long, in northwestern British Columbia in Canada and in southeast Alaska in the United States.
Its Grand Canyon represents, at this time, the top grade in difficulty for a kayak descent. Considered one of the last truly wild major rivers in British Columbia, it drains a rugged, largely pristine, area east of the Coast Mountains, cutting a fast-flowing course through the mountains in deep glacier-lined gorges to empty into Eastern Passage, just north of the city of Wrangell, which is situated at the north end of Wrangell Island in the Alexander Archipelago.